Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus

US8211923B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Holger Wagner · Mettenberg, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Ruediger Streicher · Biberach, DE
• Corinna Schoelch · Mittelbiberach, DE
• Annette Schuler-Metz · Ulm, DE
• Alexander Pautsch · Ulm, DE

Key dates

• Filing date: Jul 25, 2008
• Grant date: Jul 3, 2012
• Expiry date: Sep 3, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65586
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formulawherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.