Suppressors of CpG oligonucleotides and methods of use

US8227438B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Dennis Klinman · Potomac, US
• Rainald Zeuner · Kiel, DE
• Mayda Gursel · Ankara, TR
• Ihsan Gursel · Rockville, US
• Daniela Verthelyi · Potomac, US

Key dates

• Filing date: Feb 27, 2009
• Grant date: Jul 24, 2012
• Expiry date: Jul 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3515
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.