Oligodeoxynucleotide and its use to induce an immune response

US8227446B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Dennis Klinman · Potomac, US
• Daniela Verthelyi · Potomac, US
• Ken Ishii · Columbia, US
• James Mond · Potomac, US
• Mayda Gursel · Ankara, TR

Key dates

• Filing date: May 10, 2011
• Grant date: Jul 24, 2012
• Expiry date: May 10, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula:5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.