Inhibitors of PI3-kinases

US8232286B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Steffen Breitfelder · Aßmannshardt, DE
• Udo Maier · Senden, DE
• Trixi Brandl · Warthausen, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Matthias Grauert · Ingelheim am Rhein, DE
• Alexander Pautsch · Ulm, DE
• Matthias Hoffmann · Mittelbiberach, DE
• Frank Kalkbrenner · Berlin, DE
• Anne T. Joergensen · Copenhagen, DK
• Gerhard Schaenze · Biberach, DE
• Stefan Peters · Biberach an der Riß, DE
• Frank Buettner · Biberach an der Riß, DE
• Eckhart Bauer · Biberach, DE

Key dates

• Filing date: Feb 5, 2009
• Grant date: Jul 31, 2012
• Expiry date: Sep 27, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases.Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.