Heterocyclic benzimidazoles as TRPM8 modulators

US8232409B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Mark R. Player · Phoenixville, US
• Daniel Parks · Linglestown, US
• William H. Parsons · Montgomery, US
• Sanath K. Meegalla · Boothwyn, US
• Carl R. Illig · Phoenixville, US
• Shelley K. Ballentine · Lansdale, US

Key dates

• Filing date: Oct 9, 2009
• Grant date: Jul 31, 2012
• Expiry date: Sep 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.