Method of inducing memory B cell development and terminal differentiation

US8247228B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Catherine Ettinger · Bethesda, US
• Peter E. Lipsky · Dallas, US
• Warren J. Leonard · Bethesda, US
• Rosanne Spolski · Silver Spring, US
• Herbert C. Morse, III · Rockville, US

Key dates

• Filing date: May 23, 2008
• Grant date: Aug 21, 2012
• Expiry date: May 23, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/54
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a method for promoting differentiation of a mature naïve B cell or a B cell progenitor into a memory B cell or a plasma cell. The method comprises (a) contacting a population of cells comprising a mature naïve B cell or a B cell progenitor with an agent that activates at least one of JAK1, JAK3, STAT3, STAT5A or STAT5B; wherein the population of cells optionally is contacted with an antigen, and (b) isolating the memory B cell or plasma cell.