Imidazopyridines

US8263584B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Daniela Alberati · Zofingen, CH
• Rubén Alvarez Sánchez · Rixheim, FR
• Konrad Bleicher · Glückstadt, DE
• Alexander Flohr · Basel, CH
• Katrin Groebke Zbinden · Liestal, CH
• Matthias Koerner · Antdorf, DE
• Bernd Kuhn · Sursee, CH
• Jens-Uwe Peters · Weil am Rhein, DE
• Markus Rudolph · Basel, CH

Key dates

• Filing date: Jun 2, 2011
• Grant date: Sep 11, 2012
• Expiry date: Jun 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is concerned with novel imidazopyridine derivatives of formula (I)wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.