8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists
US8263618B2 · kind B2 · utility
17Cited by
11References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2009 |
| Grant date | Sep 11, 2012 |
| Priority date | — |
| Expiry date | Oct 14, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I):wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.