Neuropeptide-2 receptor (Y-2R) agonists and uses thereof

US8268784B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Karin Conde-Knape · Englewood, US
• Waleed Danho · Del Mar, US
• George Ehrlich · The Bronx, US
• Nader Fotouhi · Berkeley Heights, US
• David Charles Fry · Langhorne, US
• Wajiha Khan · East Hanover, US
• Anish Ashok Konkar · Guttenberg, US
• Cristina Martha Rondinone · West Milford, US
• Joseph Swistok · Nutley, US
• Rebecca Taub · Villanova, US
• Jefferson Wright Tilley · North Caldwell, US

Key dates

• Filing date: Aug 6, 2009
• Grant date: Sep 18, 2012
• Expiry date: Aug 25, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are neuropeptide-2 receptor agonists of the formula (I):as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.