Substituted pyrimidines useful as protein kinase inhibitors
US8268829B2 · kind B2 · utility
23Cited by
58References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 2009 |
| Grant date | Sep 18, 2012 |
| Priority date | — |
| Expiry date | Apr 16, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.