N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
US8278425B2 · kind B2 · utility
124Cited by
130References
30Claims
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Key dates
| Filing date | May 22, 2008 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Feb 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bicyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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