Patent · US Active

Heterocyclic gamma secretase modulators

US8288403B2 · kind B2 · utility

0Cited by

2References

24Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Karlheinz Baumann · Weil am Rhein, DE
Erwin Goetschi · Reinach, CH
Synese Jolidon · Blauen, CH
Anja Limberg · Penzberg, DE
Thomas Luebbers · Soest, DE

Key dates

Filing date	Nov 4, 2009
Grant date	Oct 16, 2012
Priority date	—
Expiry date	Oct 29, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically effective amount of a compound of formula IwhereinR1, R2, R3, V, W, Y, and Z are as defined herein or a pharmaceutically active acid addition salt of such compounds. The invention also relates to a subgenus of such compounds and pharmaceutical compositions containing them, as well as methods for their manufacture.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.