Diazole derivatives

US8293916B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Bernd Buettelmann · Palo Alto, US
• Simona M. Ceccarelli · Basel, CH
• Georg Jaeschke · Basel, CH
• Sabine Kolczewski · Lörrach, DE
• Richard Hugh Philip Porter · Sursee, CH
• Paul Spurr · Riehen, CH
• Eric Vieira · Frenkendorf, CH

Key dates

• Filing date: Nov 5, 2009
• Grant date: Oct 23, 2012
• Expiry date: Mar 29, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to diazole derivatives of the general formulawherein A, E, R1, R2 and R3 are as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of diseases mediated by the metabotropic glutamate receptors (mGluR), such as anxiety, chronic and acute pain, protection against liver damage, urinary incontinence, obesity, Fragile-X and autism, Alzheimer's disease, epilepsy, schizophrenia, ischemia, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDs, and Parkinson's disease.