Patent · US Active

Efficient production of heterologous proteins using mannosyl transferase inhibitors

US8309325B2 · kind B2 · utility

2Cited by

15References

15Claims

0Family size

Assignee

Merck Sharp & Dohme LLC · US

Inventors

Ranjit C. Desai · Colonie, US
Lihu Yang · Edison, US

Key dates

Filing date	May 18, 2009
Grant date	Nov 13, 2012
Priority date	—
Expiry date	Sep 11, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P21/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.