Patent · US Active

1′substituted carba-nucleoside analogs for antiviral treatment

US8318682B2 · kind B2 · utility

95Cited by
8References
24Claims
0Family size

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Inventors

Key dates

Filing dateAug 2, 2011
Grant dateNov 27, 2012
Priority date
Expiry dateAug 2, 2031

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted with a cyano group. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.