Pyrimidinones as casein kinase II (CK2) modulators

US8324231B2 · kind B2 · utility

Assignee

• Exelixis, Inc. · US

Inventors

• Elena S. Koltun · Foster City, US
• Patrick Kearney · San Francisco, US
• Naing Aay · San Mateo, US
• Arlyn Arcalas · South San Francisco, US
• Wai Ki Vicky Chan · San Francisco, US
• Jeffry Kimo Curtis · San Anselmo, US
• Hongwang Du · Millbrae, US
• Ping Huang · Mountain View, US
• Brian Kane · Pleasant Hill, US
• Moon Hwan Kim · Palo Alto, US
• Michael Pack · San Francisco, US
• Amy Lew Tsuhako · Milpitas, US
• Wei Xu · Saginaw, US
• Cristiana A. Zaharia · Menlo Park, US
• Peiwen Zhou · Palo Alto, US

Key dates

• Filing date: Apr 24, 2008
• Grant date: Dec 4, 2012
• Expiry date: Oct 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways.