Benzimidazoles as selective kinase inhibitors

US8329737B2 · kind B2 · utility

Assignee

• YM BIOSCIENCES AUSTRALIA PTY LTD. · AU

Inventors

• Michelle Leanne Styles · London, GB
• Jun Zeng · Torrance, US
• Herbert Rudolf Treutlein · Forbes, AU
• Andrew Frederick Wilks · Melbourne, AU
• Marcel Robert Kling · Melbourne, AU
• Xianyong Bu · Melbourne, AU
• Christopher J. Burns · Vivonne Bay, AU

Key dates

• Filing date: Sep 30, 2010
• Grant date: Dec 11, 2012
• Expiry date: Sep 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof, wherein A represents a variety of six membered nitrogen containing heterocyclic rings, Q is a bond, halogen, C1-4 alkyl, O, S, SO2, CO or CS and X1, X2, X3 and X4 are optionally substituted by 9 specific substituents or one can be nitrogen. Compositions comprising a carrier and at least one compound of formula (I) are also provided. Further provided are methods of treating tyrosine kinase-associated disease states by administering a compound of formula (I) and methods of suppressing the immune system of a subject by administering a compound of formula (I).