Solid forms of 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine

US8329912B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Thomas Cleary · Mendocino, US
• Alexander Glomme · Birsfelden, CH
• Olaf Grassmann · Soest, DE
• Shan-Ming Kuang · Florence, US
• Roland Meier · Ueken, CH
• Doreen Miller · Florence, US
• Regina Moog · Glückstadt, DE
• Franziska E. Rohrer · Riehen, CH
• Jason Yang · Florence, US

Key dates

• Filing date: Oct 14, 2011
• Grant date: Dec 11, 2012
• Expiry date: Oct 14, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations.