Monoclonal antibodies against dengue and other viruses with deletion in Fc region

US8337854B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Ana P. Goncalvez · Rockville, US
• Robert H. Purcell · Boyds, US
• Ching-Juh Lai · Bethesda, US

Key dates

• Filing date: Apr 3, 2008
• Grant date: Dec 25, 2012
• Expiry date: Feb 12, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal.