Inhibitors of P38

US8338412B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Guy Bemis · Arlington, US
• Francesco G. Salituro · Marlborough, US
• John P. Duffy · Westborough, US
• John Cochran · North Andover, US
• Edmund Harrington · Plymouth, US
• Mark A. Murcko · Holliston, US
• Keith P. Wilson · Hopkinton, US
• Michael Su · Newton, US
• Vincent Galullo · Harvard, US

Key dates

• Filing date: May 13, 2011
• Grant date: Dec 25, 2012
• Expiry date: May 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.