Raf inhibitor compounds and methods of use thereof

US8338452B2 · kind B2 · utility

Assignees

• Array BioPharma, Inc. · US
• Genentech, Inc. · US

Inventors

• Kateri A. Ahrendt · Boulder, US
• Alexandre Joseph Buckmelter · Superior, US
• Jonas Grina · Coppell, US
• Joshua Hansen · Village of La Jolla, US
• Ellen Laird · Longmont, US
• David A. Moreno · Boulder, US
• Brad Newhouse · Boulder, US
• Li Ren · Superior, US
• Steven Mark Wenglowsky · Boulder, US
• Bainian Feng · Foster City, US
• Janet Gunzner · Berkeley, US
• Kim Malesky · South San Francisco, US
• Simon Mathieu · San Francisco, US
• Joachim Rudolph · Guilford, US
• Zhaoyang Wen · South San Francisco, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: Feb 27, 2009
• Grant date: Dec 25, 2012
• Expiry date: Dec 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C311/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.