Inhibitors of histone deacetylase

US8343988B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Patrick René Angibaud · Louviers, FR
• Isabelle Noëlle Constance Pilatte · Louviers, FR
• Sven Franciscus Anna Van Brandt · Nijlen, BE
• Bruno Roux · Val-de-Reuil, FR
• Peter Ten Holte · Beerse, BE
• Marc Gustaaf Celine Verdonck · Lille, BE
• Lieven Meerpoel · Beerse, BE
• Alexey Borisovich Dyatkin · Masontown, US

Key dates

• Filing date: Feb 18, 2009
• Grant date: Jan 1, 2013
• Expiry date: Mar 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention comprises the novel compounds of formula (I)wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z andhave defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.