Process for preparing modulators of cystic fibrosis transmembrane conductance regulator

US8344147B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Narendra Bhalchandra Ambhaikar · Hyderabad, IN
• Robert Michael Hughes · San Diego, US
• Dennis James Hurley · San Marcos, US
• Elaine Chungmin Lee · Mundelein, US
• Benjamin Littler · Carlsbad, US
• Mehdi Michel Djamel Numa · San Diego, US
• Stefanie Roeper · Medford, US
• Urvi Sheth · San Diego, US

Key dates

• Filing date: Oct 21, 2010
• Grant date: Jan 1, 2013
• Expiry date: Oct 21, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.