WISP polypeptides and nucleic acids encoding same

US8350008B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• David Botstein · Belmont, US
• Robert L. Cohen · San Mateo, US
• Audrey Goddard · San Francisco, US
• Austin Gurney · Belmont, US
• Kenneth Hillan · San Francisco, US
• David Lawrence · San Francisco, US
• Arnold J. Levine · Princeton, US
• Diane Pennica · Burlingame, US
• Margaret Roy · San Francisco, US
• William I. Wood · Hillsborough, US

Key dates

• Filing date: May 26, 2011
• Grant date: Jan 8, 2013
• Expiry date: May 26, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/136
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.