Recombinant Plasmodium falciparum merozoite surface proteins 4 and 5 and their use
US8350019B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Nov 23, 2006 |
| Grant date | Jan 8, 2013 |
| Priority date | — |
| Expiry date | Sep 26, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.