Preparation of inactivated artificial antigen presenting cells and their use in cell therapies

US8357533B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Zeling Cai · San Diego, US
• Ann Moriarty · Poway, US
• Juli DeGraw · San Diego, US
• Didier Leturcq · San Diego, US
• Wei Shi · 安丰镇, CN
• Karen Kabat Stegman · Encinitas, US
• Xilian Yue · San Diego, US

Key dates

• Filing date: Jan 13, 2012
• Grant date: Jan 22, 2013
• Expiry date: Jan 13, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2239/57
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.