Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8357665B2 · kind B2 · utility
7Cited by
1References
15Claims
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Key dates
| Filing date | Oct 12, 2006 |
| Grant date | Jan 22, 2013 |
| Priority date | — |
| Expiry date | Oct 14, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.