Process for preparing N-alkylated hydroxypyrimidinone compounds

US8357798B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Kevin M. Belyk · Metuchen, US
• Henry Morrison · Dublin, US
• Philip Jones · Roma, IT
• Vincenzo Summa · Pomezia, IT
• V. Brett Cooper · Hertford, GB
• Amar J. Mahajan · Piscataway, US
• Daniel J. Kumke · Rahway, US
• Hsien-Hsin Tung · Edison, US
• Lawrence Wai · Scotch Plains, US
• Vanessa Pruzinsky · Metuchen, US
• Philip Pye · Guttenberg, US
• Remy Angelaud · San Francisco, US
• Danny Mancheno · New York, US

Key dates

• Filing date: Jun 4, 2010
• Grant date: Jan 22, 2013
• Expiry date: Sep 27, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula:Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.