Angiotensin II receptor antagonists

US8367711B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Amjad Ali · Freehold, US
• Michael Man-Chu Lo · Rahway, US
• Christopher Franklin · Keasbey, US
• Iyassu Sebhat · Jersey City, US
• Nicoletta Almirante · Milano, IT
• Silvia Stefanini · San Donato Milanese, IT
• Stefano Biondi · Verona, IT
• Ennio Ongini · Milano, IT

Key dates

• Filing date: May 30, 2012
• Grant date: Feb 5, 2013
• Expiry date: May 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)—O— and P(O)(OR6)—O—; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.