Fc variants with altered binding to FcRn

US8367805B2 · kind B2 · utility

Assignee

• Xencor, Inc. · US

Inventors

• Aaron Keith Chamberlain · San Diego, US
• Bassil Dahiyat · Altadena, US
• John Desjarlais · Pasadena, US
• Sher Bahadur Karki · Pasadena, US
• Gregory Alan Lazar · Los Angeles, US

Key dates

• Filing date: Dec 22, 2008
• Grant date: Feb 5, 2013
• Expiry date: Aug 31, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.