Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8377898B2 · kind B2 · utility
10Cited by
2References
13Claims
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Assignee
Inventors
Key dates
| Filing date | May 3, 2007 |
| Grant date | Feb 19, 2013 |
| Priority date | — |
| Expiry date | Dec 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2730/10134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.