Apoptosis signal-regulating kinase inhibitors
US8378108B2 · kind B2 · utility
45Cited by
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10Claims
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Key dates
| Filing date | Jul 12, 2010 |
| Grant date | Feb 19, 2013 |
| Priority date | — |
| Expiry date | Sep 13, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/048
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of Formula (I):where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.