Patent · US Active

Nucleic acids encoding antibodies that bind factor D

US8383802B2 · kind B2 · utility

11Cited by

16References

8Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

Michael S. C. Fung · Houston, US
William Sun · Bellaire, US
Cecily R. Y. Sun · Bellaire, US

Key dates

Filing date	Jul 2, 2012
Grant date	Feb 26, 2013
Priority date	—
Expiry date	Jul 2, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.