Positive allosteric modulators (PAM)
US8389536B2 · kind B2 · utility
1Cited by
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13Claims
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Key dates
| Filing date | Oct 20, 2010 |
| Grant date | Mar 5, 2013 |
| Priority date | — |
| Expiry date | Feb 2, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to phenylethynyl compounds of formula IwhereinR1, R2, X, L, R3, R4, R4′, cyc, and n are as defined in the specification and claims and to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They are useful for the treatment of schizophrenia or cognitive diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.