Pyrazole [3, 4-B] pyridine Raf inhibitors

US8394795B2 · kind B2 · utility

Assignees

• Array BioPharma, Inc. · US
• Genentech, Inc. · US

Inventors

• Kateri A. Ahrendt · Boulder, US
• Alexandre Joseph Buckmelter · Superior, US
• Jason De Meese · Boulder, US
• Jonas Grina · Coppell, US
• Joshua Hansen · Village of La Jolla, US
• Ellen Laird · Longmont, US
• Paul Lunghofer · Boulder, US
• David A. Moreno · Boulder, US
• Brad Newhouse · Boulder, US
• Li Ren · Superior, US
• Jeongbeob Seo · Boulder, US
• Hongqi Tian · Longmont, US
• Steven Mark Wenglowsky · Boulder, US
• Bainian Feng · Foster City, US
• Janet Gunzner · Berkeley, US
• Kim Malesky · South San Francisco, US
• Simon Mathieu · San Francisco, US
• Joachim Rudolph · Guilford, US
• Zhaoyang Wen · South San Francisco, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: Feb 27, 2009
• Grant date: Mar 12, 2013
• Expiry date: Jun 27, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C311/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.