Patent · US Active

2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease

US8394837B2 · kind B2 · utility

0Cited by

3References

14Claims

0Family size

Assignee

Merck Sharp & Dohme LLC · US

Inventors

Philippe G. Nantermet · Lansdale, US
Hemaka A. Rajapakse · Wyncote, US
Harold G. Selnick · Ambler, US
James C. Barrow · Harleysville, US
Shaun R. Stauffer · Brentwood, US
Joseph P. Vacca · Telford, US
Keith P. Moore · Doylestown, US
Shawn J. Stachel · Perkasie, US
Mattahew G. Stanton · Johnstown, US

Key dates

Filing date	Nov 18, 2005
Grant date	Mar 12, 2013
Priority date	—
Expiry date	Mar 30, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.