Patent · US Active

2,4 (4,6) pyrimidine derivatives

US8394955B2 · kind B2 · utility

0Cited by

1References

4Claims

0Family size

Assignee

Janssen Pharmaceutica NA · BE

Inventors

Eddy Jean Edgard Freyne · Rumst, BE
Marc Willems · Beerse, BE
Werner Constant Johan Embrechts · Beerse, BE
Kristof Van Emelen · Sint-Niklaas, BE
Sven Franciscus Anna Van Brandt · Nijlen, BE
Frederik Jan Rita Rombouts · Wilrijk, BE

Key dates

Filing date	Oct 20, 2011
Grant date	Mar 12, 2013
Priority date	—
Expiry date	Oct 20, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/18
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is drawn to intermediates relating to 2,4 (4,6) pyrimidine derived macrocycles, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.