Immunoglobulin insertions, deletions, and substitutions

US8399618B2 · kind B2 · utility

Assignee

• Xencor, Inc. · US

Inventors

• Gregory Alan Lazar · Los Angeles, US
• Bassil Dahiyat · Altadena, US
• Wei Dang · Pasadena, US
• Sher Bahadur Karki · Pasadena, US
• Omid Vafa · Monrovia, US

Key dates

• Filing date: Dec 23, 2011
• Grant date: Mar 19, 2013
• Expiry date: Dec 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/77
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.