Method for pressure mediated selective delivery of therapeutic substances and cannula

US8409166B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Stephen M. Wiener · Boston, US
• Robert F. Hoyt, Jr. · Boyds, US
• John R. Deleonardis · McLean, US
• Randall R. Clevenger · Mount Airy, US
• Robert J. Lutz · Wayland, US
• Douglas V. Christini · New Brunswick, US
• Brian Safer · Cumberland, US

Key dates

• Filing date: Apr 26, 2011
• Grant date: Apr 2, 2013
• Expiry date: Apr 26, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2025/0233
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery o…