Pteridinone derivatives as PI3-kinases inhibitors

US8410100B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Riccardo Giovannini · Verona, IT
• Sara Frattini · Castelleone, IT
• Trixi Brandl · Warthausen, DE
• Steffen Breitfelder · Aßmannshardt, DE
• Enzo Cereda · Novi Ligure, IT
• Matthias Grauert · Ingelheim am Rhein, DE
• Matthias Hoffman · Mittelbiberach, DE
• Anne T. Joergensen · Copenhagen, DK
• Udo Maier · Senden, DE
• Alexander Pautsch · Ulm, DE
• Monica Quai · Milano, IT
• Stefan Scheuerer · Warthausen, DE

Key dates

• Filing date: Jan 28, 2008
• Grant date: Apr 2, 2013
• Expiry date: Apr 5, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.