Imidazopyrimidine derivatives

US8410117B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Rubén Alvarez Sánchez · Rixheim, FR
• Konrad Bleicher · Glückstadt, DE
• Alexander Flohr · Basel, CH
• Luca Gobbi · Muttenz, CH
• Katrin Groebke Zbinzen · Liestal, CH
• Matthias Koerner · Antdorf, DE
• Bernd Kuhn · Sursee, CH
• Jens-Uwe Peters · Weil am Rhein, DE
• Markus Rudolph · Basel, CH

Key dates

• Filing date: Mar 17, 2011
• Grant date: Apr 2, 2013
• Expiry date: Oct 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is concerned with novel imidazopyrimidine derivatives of formula (I)wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.