Antibacterial quinoline derivatives

US8415475B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jérôme Emile Georges Guillemont · Andé, FR
• David Francis Alain Lançois · Louviers, FR
• Ismet Dorange · Nacka, SE
• Koenraad Jozef Lodewijk Marcel Andries · Beerse, BE
• Anil Koul · Edegem, BE

Key dates

• Filing date: Dec 4, 2007
• Grant date: Apr 9, 2013
• Expiry date: Dec 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib):including any stereochemically isomeric form thereof,a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof.The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.