Ube2g2 binding domain in the ubiquitin ligase gp78 and methods of use thereof

US8420776B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Allan M. Weissman · Bethesda, US
• Jennifer Mariano · Frederick, US
• Bo Chen · Jinan, CN
• Yien Che Tsai · Frederick, US

Key dates

• Filing date: Apr 27, 2005
• Grant date: Apr 16, 2013
• Expiry date: Nov 29, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/93
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2 ubiquitin conjugating enzyme. The invention further provides isolated G2BD proteins and fusion proteins. Still further provided are diagnostic and therapeutic methods, as well as screening assays utilizing compositions of the invention.