Process for the preparation of pyrido[2,1-a] isoquinoline derivatives
US8420818B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Oct 17, 2011 |
| Grant date | Apr 16, 2013 |
| Priority date | — |
| Expiry date | Oct 17, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formulawherein R2, R3 and R4 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.