Substituted pyrrolo-pyrimidine derivatives, process for their preparation and their use as kinase inhibitors

US8426417B2 · kind B2 · utility

Assignee

• NERVIANO MEDICAL SCIENCES S.R.L. · IT

Inventors

• Michele Caruso · Milano, IT
• Italo Beria · Nerviano, IT
• Maria Gabriella Brasca · Cusago, IT
• Helena Posteri · Varese, IT
• Marina Caldarelli · Milano, IT
• Walter Ceccarelli · Corsico, IT
• Barbara Valsasina · Milano, IT

Key dates

• Filing date: Sep 25, 2008
• Grant date: Apr 23, 2013
• Expiry date: Jul 25, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted pyrrolo-pyrimidine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.