CETP inhibitors derived from benzoxazole arylamides

US8436028B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Julianne A. Hunt · Scotch Plains, US
• Rogelio L. Martinez · Plainsboro, US
• Peter J. Sinclair · Highland Park, US
• Ramzi F. Sweis · Vernon Hills, US

Key dates

• Filing date: Jun 16, 2008
• Grant date: May 7, 2013
• Expiry date: May 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.