4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use

US8440663B2 · kind B2 · utility

Assignee

• Exelixis, Inc. · US

Inventors

• Grace Mann · Brisbane, US
• Naing Aay · San Mateo, US
• Arlyn Arcalas · South San Francisco, US
• S. David Brown · Redwood City, US
• Wai Ki Vicky Chan · San Francisco, US
• Jeff Chen · San Francisco, US
• Hongwang Du · Millbrae, US
• Sergey Epshteyn · Fremont, US
• Timothy Patrick Forsyth · Hayward, US
• Adam Galan · Alameda, US
• Tai Phat Huynh · Oakland, US
• Mohamed Abdulkader Ibrahim · Mountain View, US
• Henry Johnson · San Bruno, US
• Brian Kane · Pleasant Hill, US
• Patrick Kearney · San Francisco, US
• Byung Gyu Kim · Daejeon, KR
• Elena S. Koltun · Foster City, US
• James William Leahy · San Leandro, US
• Matthew Sangyup Lee · San Francisco, US
• Gary L. Lewis · San Francisco, US
• Lisa E. Meyr · Seattle, US
• Robin Tammie Noguchi · San Bruno, US
• Michael Pack · San Francisco, US
• Brian Hugh Ridgway · Belmont, US
• Xian Shi · San Bruno, US
• John Woolfrey · Los Altos, US
• Peiwen Zhou · Palo Alto, US

Key dates

• Filing date: Jan 30, 2007
• Grant date: May 14, 2013
• Expiry date: Nov 2, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.