Imidazopyrazine Syk inhibitors

US8440667B2 · kind B2 · utility

Assignee

• GILEAD CONNECTICUT, INC. · US

Inventors

• Scott A. Mitchell · East Haven, US
• Kevin S. Currie · North Branford, US
• Peter A. Blomgren · Issaquah, US
• Jeffrey E. Kropf · Branford, US
• Seung H. Lee · Sammamish, US
• Jianjun Xu · Bellevue, US
• Douglas G. Stafford · Niskayuna, US

Key dates

• Filing date: Dec 7, 2009
• Grant date: May 14, 2013
• Expiry date: Dec 7, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain imidazopyrazines of Formula (I):and pharmaceutical compositions thereof are provided herein. Methods of treating patients responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity of Formula (I) effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.