Substituted isoquinolinones and quinazolinones

US8440693B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Joerg Berghausen · Vilsbiburg, DE
• Nicole Buschmann · Basel, CH
• Pascal Furet · Basel, CH
• Francois Gessier · Illfurth, FR
• Joanna Hergovich Lisztwan · Basel, CH
• Philipp Holzer · Sissach, CH
• Edgar Jacoby · Beerse, BE
• Joerg Kallen · Basel, CH
• Keiichi Masuya · Bottmingen, CH
• Carole Pissot Soldermann · Basel, CH
• Haixia Ren · Shanghai, CN
• Stefan Stutz · Basel, CH

Key dates

• Filing date: Dec 20, 2010
• Grant date: May 14, 2013
• Expiry date: Dec 20, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I)wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.