Malaria antigen screening method

US8450055B2 · kind B2 · utility

Assignee

• United States of America as represented by the Secretary of the Air Force · US

Inventors

• Joseph T. Bruder · Urbana, US
• Imre Kovesdi · Rockville, US
• Duncan McVey · Derwood, US
• Douglas E. Brough · Olney, US
• C. Richter King · Washington, US
• Denise Louise Doolan · Brisbane, AU
• Joao Carlos Aguair · Potomac, US
• Daniel John Carucci · Washington, US
• Martha Sedegah · Gaithersburg, US
• Walter R. Weiss · Bethesda, US
• Keith Limbach · Troy, US

Key dates

• Filing date: Aug 25, 2006
• Grant date: May 28, 2013
• Expiry date: Jul 26, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.